Sphingosine-1-Phosphate Modulates Dendritic Cell Function: Focus on Non-Migratory Effects <b><i>in Vitro</i></b> and <b><i>in Vivo</i></b>

Dendritic Cell Sphingosine 1-Phosphate

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)-mediated metabolism. Although SPL is robustly expressed in thymic epithelial cells (TECs), in this study, we sh...

1 Sphingosine - 1 - Phosphate Modulates Spinal Nociceptive Processing

SPHINGOSINE-1-PHOSPHATE MODULATES SPINAL NOCICEPTIVE PROCESSING Ovidiu Coste, Christian Brenneis, Bona Linke, Sandra Pierre, Christian Maeurer, Wiebke Becker, Helmut Schmidt, Wei Gao, Gerd Geisslinger, and Klaus Scholich Running head: S1P and pain Address correspondence to: Klaus Scholich, pharmazentrum frankfurt, ZAFES, Institute for Clinical Pharmacology, Klinikum der Johann Wolfgang Goethe-U...

Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

BACKGROUND S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism. Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated within both intracellular and extracellular environments. METHODOLOGY In order to better understand the function of S1PL in this regulatory pathwa...

Plasma gelsolin modulates cellular response to sphingosine 1-phosphate.

Hypogelsolinemia is observed in patients with different states of acute or chronic inflammation such as sepsis, rheumatoid arthritis, and multiple sclerosis. In animal models of sepsis, repletion of plasma gelsolin reduces septic mortality. However, the functions of extracellular gelsolin and the mechanisms leading to its protective nature are poorly understood. Potential mechanisms involve gel...